| Primary Identifier | MGI:98086 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20020 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA-templated transcription termination; positive regulation of RNA splicing; and transcription by RNA polymerase II. Located in nucleus. Part of euchromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human POLR2A (RNA polymerase II subunit A). PHENOTYPE: Homozygotes for a reporter allele show prenatal lethality. Homozygotes for a small deletion in the C-terminal domain are viable, fertile and developmentally normal. Homozygotes for a larger deletion show reduced fetal size and partial postnatal lethality; survivors are small but otherwise normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
