| Primary Identifier | MGI:2442926 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 210529 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables mRNA m(6)A methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in brain; hindlimb; intestine; and liver. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality and decreased histone acetylation. Mice homozygous for a conditional allele activated in neuronal stem cells exhibit decreased NSC proliferation and premature differentiation and decreased number of late-born neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
