| First Author | Miura M | Year | 1993 |
| Journal | Cell | Volume | 75 |
| Issue | 4 | Pages | 653-60 |
| PubMed ID | 8242741 | Mgi Jnum | J:15702 |
| Mgi Id | MGI:63817 | Doi | 10.1016/0092-8674(93)90486-a |
| Citation | Miura M, et al. (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75(4):653-60 |
| abstractText | The mammalian interleukin-1 beta-converting enzyme (ICE) has sequence similarity to the C. elegans cell death gene ced-3. We show here that overexpression of the murine ICE (mICE) gene or of the C. elegans ced-3 gene causes Rat-1 cells to undergo programmed cell death. Point mutations in a region homologous between mICE and CED-3 eliminate the ability of mICE and ced-3 to cause cell death. The cell death caused by mICE can be suppressed by overexpression of the crmA gene, a specific inhibitor of ICE, as well as by bcl-2, a mammalian oncogene that can act to prevent programmed cell death. Our results suggest that ICE may function during mammalian development to cause programmed cell death. |
