| First Author | Guagliardo NA | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 1679 |
| PubMed ID | 32245948 | Mgi Jnum | J:287338 |
| Mgi Id | MGI:6405834 | Doi | 10.1038/s41467-020-15408-4 |
| Citation | Guagliardo NA, et al. (2020) Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun 11(1):1679 |
| abstractText | Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles in signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression of GCaMP3 and imaged zG cells within their native rosette structure. Here we demonstrate that within the rosette, angiotensin II evokes periodic Cav3-dependent calcium events that form bursts that are stereotypic in form. Our data reveal a critical role for angiotensin II in regulating burst occurrence, and a multifunctional role for the rosette structure in activity-prolongation and coordination. Combined our data define the calcium burst as the fundamental unit of zG layer activity evoked by angiotensin II and highlight a novel role for the rosette as a facilitator of cell communication. |
