| First Author | Nam TW | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 514 |
| Issue | 4 | Pages | 1087-1092 |
| PubMed ID | 31097220 | Mgi Jnum | J:279693 |
| Mgi Id | MGI:6363907 | Doi | 10.1016/j.bbrc.2019.04.186 |
| Citation | Nam TW, et al. (2019) Effect of EI24 expression on the tumorigenesis of Apc(Min/+) colorectal cancer mouse model. Biochem Biophys Res Commun 514(4):1087-1092 |
| abstractText | Etoposide-induced 2.4kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the physiological function of EI24 in colorectal cancer is yet unclear. We generated an Ei24 conditional transgenic (Tg) mouse to study the therapeutic effects of Ei24 in vivo and evaluated whether Ei24 plays a role of a tumor suppressor using Ei24 Tg mouse crossed with Apc(Min/+) mouse, which develops multiple intestinal adenomas. The overexpression of Ei24 failed to cause any notable difference in the number of polyps, lengths of the intestine and spleen, and survival rate between Apc(Min/+) and Apc(Min/+)Ei24 Tg mice. Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice. Therefore, our result dismisses the hypothesized direct link between Apc(Min/+) mutation and Ei24 expression in colorectal cancer model. |
