| First Author | Calakos N | Year | 2004 |
| Journal | Neuron | Volume | 42 |
| Issue | 6 | Pages | 889-96 |
| PubMed ID | 15207234 | Mgi Jnum | J:107731 |
| Mgi Id | MGI:3621832 | Doi | 10.1016/j.neuron.2004.05.014 |
| Citation | Calakos N, et al. (2004) Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron 42(6):889-96 |
| abstractText | The active zone protein RIM1alpha interacts with multiple active zone and synaptic vesicle proteins and is implicated in short- and long-term synaptic plasticity, but it is unclear how RIM1alpha's biochemical interactions translate into physiological functions. To address this question, we analyzed synaptic transmission in autaptic neurons cultured from RIM1alpha-/- mice. Deletion of RIM1alpha causes a large reduction in the readily releasable pool of vesicles, alters short-term plasticity, and changes the properties of evoked asynchronous release. Lack of RIM1alpha, however, had no effect on synapse formation, spontaneous release, overall Ca2+ sensitivity of release, or synaptic vesicle recycling. These results suggest that RIM1alpha modulates sequential steps in synaptic vesicle exocytosis through serial protein-protein interactions and that this modulation is the basis for RIM1alpha's role in synaptic plasticity. |
