| First Author | Newton K | Year | 1998 |
| Journal | EMBO J | Volume | 17 |
| Issue | 3 | Pages | 706-18 |
| PubMed ID | 9450996 | Mgi Jnum | J:110608 |
| Mgi Id | MGI:3640724 | Doi | 10.1093/emboj/17.3.706 |
| Citation | Newton K, et al. (1998) A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 17(3):706-18 |
| abstractText | Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities. They induce apoptosis via interaction with intracellular FADD/MORT1 and trigger cell growth or differentiation via TRADD and TRAF molecules. The impact of FADD/MORT1-transduced signals on T lymphocyte development was investigated in transgenic mice expressing a dominant negative mutant protein, FADD-DN. Unexpectedly, FADD-DN enhanced negative selection of self-reactive thymic lymphocytes and inhibited T cell activation by increasing apoptosis. Thus signalling through FADD/MORT1 does not lead exclusively to cell death, but under certain circumstances can promote cell survival and proliferation. |
