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Protein Coding Gene : Lclat1 lysocardiolipin acyltransferase 1

Primary Identifier  MGI:2684937 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  225010
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within phospholipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including gut; heart; immune system; ovary; and respiratory system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1).
PHENOTYPE: Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation. [provided by MGI curators]
  • synonyms:
  • lysocardiolipin acyltransferase 1,
  • Gm91,
  • gene model 91, (NCBI),
  • expressed sequence AI181996,
  • AI181996,
  • AGPAT8,
  • ALCAT1,
  • MGI:2146804,
  • lysocardiolipin acyltransferase,
  • Lclat1,
  • Lycat

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For