| First Author | Takahashi H | Year | 1997 |
| Journal | Gene | Volume | 197 |
| Issue | 1-2 | Pages | 383-7 |
| PubMed ID | 9332390 | Mgi Jnum | J:42986 |
| Mgi Id | MGI:1096939 | Doi | 10.1016/s0378-1119(97)00294-1 |
| Citation | Takahashi H, et al. (1997) Cloning of cDNA and expression of the gene encoding rat presenilin-2. Gene 197(1-2):383-7 |
| abstractText | We have cloned the rat homologue of the presenilin-2 (PS-2) cDNA. PS-2 is responsible for chromosome 1-linked familial Alzheimer's disease. Sequence analysis predicted that the rat PS-2 encodes a 448 amino acid (aa) protein, and there was a very high degree of amino acid identity between rat and human PS-2 (95%). All the mutated codons in PS-2 and PS-1 in chromosome 1- or 14-linked familial Alzheimer's disease patients were conserved in rat PS-2. The expression of PS-2 was weaker than that of PS-1. The alternatively spliced short form of PS-2 mRNA, which was detected in human tissues was not detected in various rat tissues. During brain development, the expression level of both PS-2 and PS-1 increased but decreased in the adult. No remarkable change was observed in neural differentiation of PC12 cells. |
