|  Help  |  About  |  Contact Us

Protein Coding Gene : Nfasc neurofascin

Primary Identifier  MGI:104753 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  269116
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in paranodal junction assembly. Acts upstream of or within several processes, including neuron development; protein localization to axon; and transmission of nerve impulse. Located in several cellular components, including main axon; paranodal junction; and septate junction. Is expressed in nervous system and neural retina. Orthologous to human NFASC (neurofascin).
PHENOTYPE: Mice homozygous for a null allele die within 6 to 7 days of birth, exhibit reduced nerve conduction velocity and abnormal paranodal junction formation. [provided by MGI curators]
  • synonyms:
  • mKIAA0756,
  • D430023G06Rik,
  • expressed sequence AA387016,
  • Nfasc,
  • NF155,
  • NF186,
  • AA387016,
  • neurofascin,
  • MGI:3035338,
  • MGI:2442229,
  • RIKEN cDNA D430023G06 gene,
  • MGD-MRK-28044

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

3 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For