| First Author | Dodig TD | Year | 2001 |
| Journal | Arthritis Rheum | Volume | 44 |
| Issue | 3 | Pages | 723-7 |
| PubMed ID | 11263788 | Mgi Jnum | J:112962 |
| Mgi Id | MGI:3664140 | Doi | 10.1002/1529-0131(200103)44:3<723::AID-ANR122>3.0.CO;2-V |
| Citation | Dodig TD, et al. (2001) Development of the tight-skin phenotype in immune-deficient mice. Arthritis Rheum 44(3):723-7 |
| abstractText | OBJECTIVE: To determine if cutaneous thickening, a major phenotypic feature of the tight-skin (Tsk) mutation, could develop in an immune-deficient mouse. METHODS: Experimental crosses among different strains of mice were conducted to create mice that were genetically Tsk/+, and that were also homozygous for a mutation at the Prkdc(scid) locus and thus lacked mature T and B lymphocytes. Skin samples prepared from experimental and control genotypic groups of mice were evaluated for skin thickness. RESULTS: The data showed that the Tsk/+ mice developed the Tsk phenotype in the absence of a functional immune system. CONCLUSION: Mature T and B cells are not required for the development of the cutaneous thickening in mice carrying the Tsk mutation. |
