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Protein Coding Gene : C2 complement C2
Primary Identifier  MGI:88226 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  12263
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in complement activation; positive regulation of apoptotic cell clearance; and response to bacterium. Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and proteolysis. Located in extracellular space. Is expressed in several structures, including hemolymphoid system; liver; metanephros; placenta; and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2).
  • synonyms:
  • MGD-MRK-1699,
  • C2,
  • complement C2,
  • classical-complement pathway C3/C5 convertase
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For





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