| Primary Identifier | MGI:3576786 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Adamts5 |
| Transmission | Germline | Strain of Origin | 129S/SvEvBrd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was flanked with loxP sites to allow disruption of the zinc-binding site and deletion of the conserved "Met-turn." Cre mediated recombination of the flanking loxP sites resulted in the deletion of exon 3 from Adamts5tm1Eam. RT-PCR confirmed absence of exon 3 in mutant spleen and cartilage transcripts. A protein product from the transcript was not found in mutant cartilage. |
