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Protein Coding Gene : Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha

Primary Identifier  MGI:1926334 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  51792
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables protein serine/threonine phosphatase activity. Involved in T cell homeostasis and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including meiotic sister chromatid cohesion, centromeric; nuclear division; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol. Part of protein phosphatase type 2A complex. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha).
PHENOTYPE: Mice homozygous for a targeted allele that remove exons 5 and 6 exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased benzopyrene-induced lung tumors. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 6330556D22 gene,
  • MGI:1923432,
  • protein phosphatase 2, regulatory subunit A, alpha,
  • PP2A,
  • protein phosphatase PP2A,
  • PR65,
  • 6330556D22Rik,
  • Ppp2r1a

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

120 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For