| Primary Identifier | IPR011142 | Type | Conserved_site |
| Short Name | Spider_toxin_CSTX_Knottin_CS |
| description | Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot structural motif or Knottin scaffold (https://www.dsimb.inserm.fr/KNOTTIN/). The four disulphide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. This family includes: Cupiennius salei (Wandering spider) toxin CSTX-1 and its proteolytic products CSTX-2a and CSTX-2b []. C. salei (Wandering spider) CSTX-9 []. C. salei (Wandering spider) CSTX-13, a neurotoxic enhancer. In contrast to CSTX-1 and CSTX-9, CSTX-13 is a two-chain peptide with two interchain and two intrachain disulphide bridges []. |
