| First Author | Cory S | Year | 2002 |
| Journal | Nat Rev Cancer | Volume | 2 |
| Issue | 9 | Pages | 647-56 |
| PubMed ID | 12209154 | Mgi Jnum | J:79249 |
| Mgi Id | MGI:2387571 | Doi | 10.1038/nrc883 |
| Citation | Cory S, et al. (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2(9):647-56 |
| abstractText | Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches. |
