| First Author | Pan C | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 4 | Pages | 495-506 |
| PubMed ID | 10549631 | Mgi Jnum | J:76990 |
| Mgi Id | MGI:2180741 | Doi | 10.1016/s1074-7613(00)80124-7 |
| Citation | Pan C, et al. (1999) CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11(4):495-506 |
| abstractText | CD72, a B cell surface protein of the C-type lectin superfamily, recruits the tyrosine phosphatase SHP-1 through its ITIM motif(s). Using CD72-deficient (CD72-/-) mice, we demonstrate that CD72 is a nonredundant regulator of B cell development. In the bone marrow of CD72-/- mice, there was a reduction in the number of mature recirculating B cells and an accumulation of pre-B cells. In the periphery of CD72-/- mice, there were fewer mature B-2 cells and more B-1 cells. In addition, CD72 is a negative regulator of B cell activation, as CD72-/- B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking. |
