Primary Identifier | MGI:2450327 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Sptbn1 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A 2.2 kb fragment containing the 25th exon was replaced with a neomycin selection cassette. The deleted region encodes 114 amino acids that make up the a portion of the ankyrin binding domain. Western blot analysis of homozygous mutant embryos indicated an absence of normal protein. |