| First Author | Tan NS | Year | 2005 |
| Journal | J Biol Chem | Volume | 280 |
| Issue | 18 | Pages | 18163-70 |
| PubMed ID | 15708854 | Mgi Jnum | J:109975 |
| Mgi Id | MGI:3630193 | Doi | 10.1074/jbc.M412829200 |
| Citation | Tan NS, et al. (2005) Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem 280(18):18163-70 |
| abstractText | Advances in wound care are of great importance in clinical injury management. In this respect, the nuclear receptor peroxisome proliferator-activated receptor (PPAR)beta/delta occupies a unique position at the intersection of diverse inflammatory or anti-inflammatory signals that influence wound repair. This study shows how changes in PPARbeta/delta expression have a profound effect on wound healing. Using two different in vivo models based on topical application of recombinant transforming growth factor (TGF)-beta1 and ablation of the Smad3 gene, we show that prolonged expression and activity of PPARbeta/delta accelerate wound closure. The results reveal a dual role of TGF-beta1 as a chemoattractant of inflammatory cells and repressor of inflammation-induced PPARbeta/delta expression. Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-beta1 at wound sites. |
