| First Author | Asayesh A | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 16 | Pages | 2208-13 |
| PubMed ID | 16912273 | Mgi Jnum | J:111685 |
| Mgi Id | MGI:3654726 | Doi | 10.1101/gad.381906 |
| Citation | Asayesh A, et al. (2006) Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev 20(16):2208-13 |
| abstractText | During early stages of pancreatic development, the mesenchyme that contributes to the spleen overlies the dorsal pancreatic endoderm. Here, we show that interactions between splenic mesenchyme and pancreas proceed via a highly orchestrated morphogenetic program. Disruption of morphogenesis, as occurs in the Bapx1(Nkx3.2)(-/-) embryo, results in transformation of these tissues into well-organized, ectopic gut-like structures. Bapx1 plays a crucial organizing role effecting position and separation of the spleen and pancreas to prevent this metaplastic transformation. Similar transformations occur in organ cultures employing wild-type pancreatic endoderm and spleen mesenchyme, revealing the developmental plasticity of the pancreas and that precise spatial and temporal control of tissue interactions are required for development of both organs. |
