| First Author | Best JL | Year | 2002 |
| Journal | Mol Cell | Volume | 10 |
| Issue | 4 | Pages | 843-55 |
| PubMed ID | 12419228 | Mgi Jnum | J:84904 |
| Mgi Id | MGI:2670563 | Doi | 10.1016/s1097-2765(02)00699-8 |
| Citation | Best JL, et al. (2002) SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell 10(4):843-55 |
| abstractText | During a screen to identify c-Jun activators, we isolated a cysteine protease, SuPr-1, that induced c-Jun-dependent transcription independently of c-Jun phosphorylation. SuPr-1 is a member of a new family of proteases that hydrolyze the ubiquitin-like modifier, SUMO-1. SuPr-1 hydrolyzed SUMO-1-modified forms of the promyelocytic leukemia gene product, PML, and altered the subcellular distribution of PML in nuclear PODs (PML oncogenic domains). SuPr-1 also altered the distribution of other nuclear POD-associated proteins, such as CBP and Daxx, that act as transcriptional regulators. SuPr-1 action on transcription was enhanced by PML, and SuPr-1 failed to activate transcription in PML-deficient fibroblasts. Our studies establish an important role for SUMO proteases in transcription. |
