| First Author | Bucher P | Year | 1997 |
| Journal | Immunobiology | Volume | 198 |
| Issue | 1-3 | Pages | 136-43 |
| PubMed ID | 9442385 | Mgi Jnum | J:45251 |
| Mgi Id | MGI:1194697 | Doi | 10.1016/s0171-2985(97)80034-4 |
| Citation | Bucher P, et al. (1997) A conserved IL-2 responsive enhancer in the IL-2R alpha gene. Immunobiology 198(1-3):136-43 |
| abstractText | IL-2 stimulates expression of the alpha subunit of the high affinity IL-2 receptor (IL-2R alpha) in antigen-activated T lymphocytes, by increasing IL-2R alpha gene transcription. This response is mediated by a 52 nt IL-2 responsive enhancer (IL-2rE) that is conserved between mouse and man. The mouse enhancer is 1.3 kb upstream of the transcription start site and co-localizes with an inducible Dnasel hypersensitive site, whereas the human homologue maps to -4 kb. The human IL-2rE is functional in rodent cells. Both enhancers contain two potential STAT binding sites and an Ets consensus motif. One of the STAT motifs overlaps with a binding site for GATA factors. Functional analysis of the mouse and human enhancers indicates that IL-2-activated STAT5 and the constitutively active Ets protein Elf-1 play a predominant role in controlling IL-2rE activity. |
