| Primary Identifier | MGI:2684956 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 227631 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within oogenesis; ovarian follicle development; and positive regulation of DNA-templated transcription. Located in cytoplasm and male germ cell nucleus. Is expressed in gonad and hindlimb long bone. Human ortholog(s) of this gene implicated in ovarian dysgenesis 5 and spermatogenic failure 32. Orthologous to human SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1). PHENOTYPE: Males homozygous for a null allele show decreased testis weight and male infertility due to defective spermatogonial differentiation into spermatocytes. Females are also infertile and show defective primordial-to-primary follicle transition and atrophic ovaries with rapid postnatal loss of oocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
