| First Author | Baird AM | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 7 | Pages | 3680-8 |
| PubMed ID | 11034372 | Mgi Jnum | J:64861 |
| Mgi Id | MGI:1890055 | Doi | 10.4049/jimmunol.165.7.3680 |
| Citation | Baird AM, et al. (2000) A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol 165(7):3680-8 |
| abstractText | Humans and mice with genetic deficiencies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptors have severe defects in B and T lymphocytes. In humans, these deficiencies lead to a complete absence of T cells, whereas in mice, small thymuses give rise to normal numbers of peripheral T cells. We have examined the first wave of developing T cells in Jak3-/-, IL-7-/-, and IL-7Ralpha-/- fetal mice, and have found a near absence of thymic progenitor cells. This deficiency is highlighted by the complete inability of Jak3-/- progenitor cells to reconstitute T cell development in the presence of competing wild-type cells. These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gammac/Jak3 signaling pathways. |
