| First Author | Cariappa A | Year | 2007 |
| Journal | Blood | Volume | 109 |
| Issue | 6 | Pages | 2339-45 |
| PubMed ID | 17119110 | Mgi Jnum | J:145353 |
| Mgi Id | MGI:3834338 | Doi | 10.1182/blood-2006-05-021089 |
| Citation | Cariappa A, et al. (2007) Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood 109(6):2339-45 |
| abstractText | We have recently demonstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD(hi) naive recirculating B cells, but the existence of mutant mice that have selectively lost mature B cells in the bone marrow prompted an examination of B-cell maturation at this latter site. Following a single pulse of BrdU in intact mice, sequential labeling of more mature B-cell populations in the bone marrow suggested ongoing maturation at this site. Further evidence for B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary lymphoid organs. In these mice, antibody-secreting cells recognizing multivalent antigens were also observed in the bone marrow following an intravenous microbial challenge. These data suggest that newly formed B cells mature into IgD(hi) B cells simultaneously in the spleen and the bone marrow and establish in a stringent manner that humoral immune responses can be initiated in situ in the bone marrow. |
