| First Author | Kubo KY | Year | 2008 |
| Journal | Neurosci Lett | Volume | 441 |
| Issue | 2 | Pages | 141-4 |
| PubMed ID | 18614288 | Mgi Jnum | J:138870 |
| Mgi Id | MGI:3806742 | Doi | 10.1016/j.neulet.2008.05.027 |
| Citation | Kubo KY, et al. (2008) The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region. Neurosci Lett 441(2):141-4 |
| abstractText | The present study examined the effect of the bite-raised condition on the number of dendritic spines on hippocampal pyramidal cells in SAMP8 mice and related the results with learning ability in a water maze test. Aged mice in the bite-raised condition had reduced learning ability and a lower number of CA1 pyramidal cell dendritic spines. The results suggest that the bite-raised condition exacerbates the age-related spatial learning impairment, and that this may be due to the degeneration of hippocampal dendritic spines. |
