| First Author | Angelotti T | Year | 1996 |
| Journal | FEBS Lett | Volume | 397 |
| Issue | 2-3 | Pages | 331-7 |
| PubMed ID | 8955374 | Mgi Jnum | J:36720 |
| Mgi Id | MGI:84146 | Doi | 10.1016/s0014-5793(96)01205-7 |
| Citation | Angelotti T, et al. (1996) Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit. FEBS Lett 397(2-3):331-7 |
| abstractText | Five different splice variants of mouse alpha2/delta subunit isoforms (alpha2a-e), which arose from various combinations of three alternatively spliced regions, were cloned with a combination of cDNA library screening and RT-PCR. Expression patterns and relative abundance of the various isoforms in mouse tissues were determined with an RNAse protection assay. Skeletal muscle and brain expressed single isoforms, alpha2a and alpha2b, respectively; however, the cardiovascular system expressed all five isoforms. Heart expressed mainly isoforms alpha2c and alpha2d while, in contrast to other species, aorta expressed predominantly alpha2a, the 'skeletal muscle' isoform. Smooth muscle-containing tissues expressed alpha2d and alpha2e. Thus, alpha2/delta isoforms are restricted in their tissue expression, suggesting an important functional role for the differentially spliced variants. |
