| First Author | Kile BT | Year | 2002 |
| Journal | Trends Biochem Sci | Volume | 27 |
| Issue | 5 | Pages | 235-41 |
| PubMed ID | 12076535 | Mgi Jnum | J:82306 |
| Mgi Id | MGI:2652169 | Doi | 10.1016/s0968-0004(02)02085-6 |
| Citation | Kile BT, et al. (2002) The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 27(5):235-41 |
| abstractText | Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation. |
