| Primary Identifier | MGI:88075 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 11881 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables N-acetylgalactosamine-6-sulfatase activity and arylsulfatase activity. Involved in dermatan sulfate catabolic process. Acts upstream of or within anterior head development. Located in cell surface. Is active in lysosome. Is expressed in skeleton. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). PHENOTYPE: Homozygous mutation of this gene results in development of shortened limbs and snout and a broadened head after 4 weeks of age. Mutant animals have elevated concentrations of glucosaminoglycans in the urine and irregular cartilage structure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
