| First Author | Zhang M | Year | 2006 |
| Journal | J Mol Cell Cardiol | Volume | 41 |
| Issue | 1 | Pages | 62-7 |
| PubMed ID | 16781728 | Mgi Jnum | J:110959 |
| Mgi Id | MGI:3652452 | Doi | 10.1016/j.yjmcc.2006.02.006 |
| Citation | Zhang M, et al. (2006) The role of natural IgM in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 41(1):62-7 |
| abstractText | Myocardial ischemia-reperfusion injury represents a combination of factors, namely the intrinsic cellular response to ischemia and the extrinsic acute inflammatory response. Recent studies in mesenteric and skeletal muscle reperfusion models identified natural IgM as a major initiator of pathology through the activation of the complement system and inflammatory cells. To determine whether a similar mechanism is involved in myocardial tissues, mice bearing an altered natural IgM repertoire (Cr2(-/-)) were examined in a murine model of coronary artery ischemia. Notably, these mice were significantly protected based on the reduced infarct size, limited apoptosis of cardiomyocytes, and decreased neutrophil infiltration. Protection was IgM-dependent as reconstitution of these mice with wild-type IgM restored myocardial reperfusion injury. These results support a model in which natural IgM initiates the acute inflammatory response in the myocardium following ischemia and reperfusion. |
