| First Author | Bradley A | Year | 2007 |
| Journal | MGI Direct Data Submission | Mgi Jnum | J:115975 |
| Mgi Id | MGI:3692539 | Citation | Bradley A, et al. (2007) The albino B6 line, C57BL/6-Tyrc-Brd. MGI Direct Data Submission |
| abstractText | -------- Original Message -------- Subject: Albino B6 line Date: Wed, 3 Jan 2007 15:08:14 +0000 From: Allan Bradley <abradley@sanger.ac.uk> To: Beverly Richards-Smith <brs@informatics.jax.org> Hi, Tyr-c-Brd arose as a spontaneous mutation in my B6 colony in about 1991. Two years ago I provided some information to Rivka Rachel on this line - copied below. Information back from Rivka (also copied below) suggests that the mutation in our line is the same as that in the c2J allele. I'm not clear if these mice carry the a polymorphism/variant form of RPE65 that is found in c2J, but I would guess not. You may wish to confirm this with Rivka. Regards, Allan Bradley ______________________________________________________________ X-Sieve: CMU Sieve 2.2 Envelope-to: abradley@sanger.ac.uk Date: Mon, 21 Mar 2005 15:15:47 -0500 To: Allan Bradley <abradley@sanger.ac.uk> From: "Rivka A. Rachel" <rrachel@ncifcrf.gov> Subject: Re: Albino mice X-Scanned: Sanger Spam Scanner (extmail2.sanger.ac.uk) Dear Dr. Bradley, We ran the sequencing reactions on tyrosinase exon 1 for the three DNA samples that you had Lucy send, and all of them contained the same G-->T codon 291 mutation found in the albino mice in our colony, as well as in the c2J mice from Jax. It was out of interest for us at this point, since our goal was to identify the mutation in our mice in order to distinguish +/c mice from +/+, and the sequencing does this very well. Best regards, Rivka Rivka -- ~~~~~~~~~~~~~~~~~~~~~~~~~~~ Rivka A. Rachel, MD, PhD Staff Scientist, Mouse Cancer Genetics Program National Cancer Institute-Frederick West Seventh Street at Ft. Detrick P.O. Box B, Bldg. 539, Room 234 Frederick, MD 21702-1201 Lab: (301) 846-6083 Office: (301) 846-6185 Fax: (301) 846-6666 ------------------------------- > Dear Rivka, > > I have no information on our allele, except that we believe it is point mutation in the tyrosinase gene, though we never sought any direct evidence for this. Evidence that this assumption is correct comes from 4 observations: (i) the mice are white including their eyes, (ii) the mutation occasionally reverts (black pups appear in the albino litters) at a very low frequency (I have been told of 2 in our colony since 1992) (iii) The mutation lies at the Try locus on chromosome 7, we have used this linkage for other purposes (iv) the mutation can be complemented with a Tyrmingene (we have published 3 examples of this). Regards, Allan Bradley |
