| Primary Identifier | MGI:104556 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 12575 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including cellular response to UV-B; cellular response to amino acid starvation; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including cellular response to gamma radiation; regulation of macromolecule biosynthetic process; and signal transduction by p53 class mediator. Located in cytosol. Part of cyclin-dependent protein kinase holoenzyme complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study hepatocellular carcinoma; systemic lupus erythematosus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A). PHENOTYPE: Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
