| Primary Identifier | MGI:1312922 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12364 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cysteine-type endopeptidase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and self proteolysis. Acts upstream of or within endoplasmic reticulum unfolded protein response and fibroblast apoptotic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)). PHENOTYPE: Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
