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Publication : Primary structure of mouse secretogranin III and its absence from deficient mice.

First Author  Dopazo A Year  1993
Journal  J Mol Neurosci Volume  4
Issue  4 Pages  225-33
PubMed ID  7917832 Mgi Jnum  J:19247
Mgi Id  MGI:67434 Doi  10.1007/BF02821554
Citation  Dopazo A, et al. (1993) Primary structure of mouse secretogranin III and its absence from deficient mice. J Mol Neurosci 4(4):225-33
abstractText  The rat brain- and pituitary-specific 1B1075 mRNA encodes a chromogranin/secretogranin-like protein, called secretogranin III (SgIII), that is a component of intracellular dense core vesicles. In order to study the function of this gene product in a mouse model system, we have isolated the murine homolog of the rat 1B1075 mRNA. This mRNA contains 2163 bp encoding a putative protein of 421 amino acids. Cleavage of the strong putative signal sequence would yield a mature protein of 51 kDa. The sequence of the encoded murine protein preserves the structural features that suggest SgIII is a member of the granin family, and allowed us to recognize and correct errors in our published rat sequence.
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