First Author | Dopazo A | Year | 1993 |
Journal | J Mol Neurosci | Volume | 4 |
Issue | 4 | Pages | 225-33 |
PubMed ID | 7917832 | Mgi Jnum | J:19247 |
Mgi Id | MGI:67434 | Doi | 10.1007/BF02821554 |
Citation | Dopazo A, et al. (1993) Primary structure of mouse secretogranin III and its absence from deficient mice. J Mol Neurosci 4(4):225-33 |
abstractText | The rat brain- and pituitary-specific 1B1075 mRNA encodes a chromogranin/secretogranin-like protein, called secretogranin III (SgIII), that is a component of intracellular dense core vesicles. In order to study the function of this gene product in a mouse model system, we have isolated the murine homolog of the rat 1B1075 mRNA. This mRNA contains 2163 bp encoding a putative protein of 421 amino acids. Cleavage of the strong putative signal sequence would yield a mature protein of 51 kDa. The sequence of the encoded murine protein preserves the structural features that suggest SgIII is a member of the granin family, and allowed us to recognize and correct errors in our published rat sequence. |