| Primary Identifier | IPR033611 | Type | Family |
| Short Name | IRAK2 |
| description | Interleukin-1 receptor-associated kinase-like 2 (IRAK2) is a critical mediator of TLR/IL1-R signalling [, ]. It is required for production of pro-inflammatory cytokines [, ].All IRAKs are multidomain proteins, consisting of a conserved N-terminal death domain (DD) and a central kinase domain (KD). The DD is a protein interaction motif implicated in binding to the adaptor protein MyD88 []. IRAK2 lacks an active kinase domain, as a critical residue in the kinase domain has changed []. |
