First Author | Whitehouse DB | Year | 1992 |
Journal | Proc Natl Acad Sci U S A | Volume | 89 |
Issue | 1 | Pages | 411-5 |
PubMed ID | 1530890 | Mgi Jnum | J:439 |
Mgi Id | MGI:48976 | Doi | 10.1073/pnas.89.1.411 |
Citation | Whitehouse DB, et al. (1992) Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1. Proc Natl Acad Sci U S A 89(1):411-5 |
abstractText | A cDNA clone encoding the mRNA for the highly polymorphic human enzyme phosphoglucomutase 1 (PGM1; EC 5.4.2.2) has been isolated and characterized. This was achieved indirectly by first isolating a rabbit cDNA from an expression library using anti-rabbit PGM antibodies. A comparison of the nucleotide sequences shows that the homologies between human and rabbit PGM1 mRNAs are 92% and 97% for the coding nucleotide sequence and the amino acid sequence, respectively. The derived rabbit amino acid sequence is in complete agreement with the published protein sequence for rabbit muscle PGM. A physical localization of the human PGM1 gene to chromosome 1p31 has been determined by in situ hybridization. Analysis of DNA from a wide variety of vertebrates indicates a high level of PGM1 sequence conservation during evolution. |