| First Author | Lewin DA | Year | 1998 |
| Journal | FEBS Lett | Volume | 435 |
| Issue | 2-3 | Pages | 263-8 |
| PubMed ID | 9762922 | Mgi Jnum | J:50123 |
| Mgi Id | MGI:1289937 | Doi | 10.1016/s0014-5793(98)01083-7 |
| Citation | Lewin DA, et al. (1998) Cloning, expression, and localization of a novel gamma-adaptin-like molecule. FEBS Lett 435(2-3):263-8 |
| abstractText | We describe the cloning, expression, and localization of gamma2-adaptin, a novel isoform of gamma-adaptin. The predicted human and mouse gamma2-adaptin proteins are approximately 90 kDa and 64.4% and 61.7%) identical to gamma-adaptin, respectively. gamma2-Adaptin was localized to the Golgi, its localization distinct from gamma-adaptin. The membrane association of gamma- and gamma2-adaptin could further be distinguished by differential sensitivity to the fungal metabolite brefeldin A, gamma2-adaptin binding being insensitive to drug treatment. Together, these results suggest that gamma2-adaptin plays a role in membrane transport distinct from that played by gamma-adaptin. |
