| First Author | Szpak Y | Year | 2001 |
| Journal | Proc Natl Acad Sci U S A | Volume | 98 |
| Issue | 5 | Pages | 2572-6 |
| PubMed ID | 11226280 | Mgi Jnum | J:67871 |
| Mgi Id | MGI:1931644 | Doi | 10.1073/pnas.051595998 |
| Citation | Szpak Y, et al. (2001) Spontaneous retinopathy in HLA-A29 transgenic mice. Proc Natl Acad Sci U S A 98(5):2572-6 |
| abstractText | Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with retinal vasculopathy and inflammatory signs causing damage to the ocular structures, leading regularly to visual loss. To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into mice. Aging HLA-A29 transgenic mice spontaneously developed retinopathy, showing a striking resemblance to the HLA-A29-associated chorioretinopathy. These results strongly suggest that HLA-A29 is involved in the pathogenesis of this disease. Elucidation of the role of HLA-A29 should be assisted by this transgenic model. |
