| First Author | Girardin SE | Year | 2003 |
| Journal | Science | Volume | 300 |
| Issue | 5625 | Pages | 1584-7 |
| PubMed ID | 12791997 | Mgi Jnum | J:161659 |
| Mgi Id | MGI:4460826 | Doi | 10.1126/science.1084677 |
| Citation | Girardin SE, et al. (2003) Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300(5625):1584-7 |
| abstractText | Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing. |
