| First Author | Yamaguchi F | Year | 1999 |
| Journal | FEBS Lett | Volume | 459 |
| Issue | 1 | Pages | 105-10 |
| PubMed ID | 10508926 | Mgi Jnum | J:57941 |
| Mgi Id | MGI:1346227 | Doi | 10.1016/s0014-5793(99)01210-7 |
| Citation | Yamaguchi F, et al. (1999) Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome. FEBS Lett 459(1):105-10 |
| abstractText | EDG-3 is a receptor for sphingosine-1-phosphate mapped on human chromosome 9q22.1-q22.2. We used the compact Fugu genome for its linkage analysis. The Fugu EDG-3 was composed of one intron and two exons, encoding a 384 amino acid protein that has 56.9% homology with the human EDG-3. Approximately 3 kb apart, a neuronal Shc (N-Shc) gene was identified. It spans 7 kb containing 12 coding exons, and has an overall 53.4% similarity with the human protein. We mapped the human N-Shc gene to chromosome 9q21.3-q22.2. This is the first report of the genomic structure and the linkage of these two genes conserved between Fugu and human. |
