| First Author | Rogers PR | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 3 | Pages | 445-55 |
| PubMed ID | 11567634 | Mgi Jnum | J:71803 |
| Mgi Id | MGI:2150820 | Doi | 10.1016/s1074-7613(01)00191-1 |
| Citation | Rogers PR, et al. (2001) OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15(3):445-55 |
| abstractText | It is important to understand which molecules are essential for long-lived immunity. We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion. In contrast to CD28-/- T cells, which show defects early, OX40-/- T cells are relatively unimpaired in IL-2 production, cell division, and expansion. However, OX40-/- T cells fail to maintain high levels of Bcl-xL and Bcl-2 4-8 days after activation, and undergo apoptosis. Conversely, OX40 stimulation promotes Bcl-xL and Bcl-2 and suppresses apoptosis. Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival. |
