| First Author | Sommers CL | Year | 2008 |
| Journal | Int Immunol | Volume | 20 |
| Issue | 7 | Pages | 811-8 |
| PubMed ID | 18448454 | Mgi Jnum | J:136655 |
| Mgi Id | MGI:3796754 | Doi | 10.1093/intimm/dxn039 |
| Citation | Sommers CL, et al. (2008) Bam32: a novel mediator of Erk activation in T cells. Int Immunol 20(7):811-8 |
| abstractText | Bam32 (B lymphocyte adapter molecule of 32 kDa) is an adapter protein expressed in some hematopoietic cells including B and T lymphocytes. It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including B cell receptor (BCR)-induced Erk activation, BCR-induced proliferation and T-independent antibody responses. In this study, we have examined the role of Bam32 in T cell activation using Bam32-deficient mice. By comparing CD4(+) T cells from lymph nodes of wild-type and Bam32-deficient mice, we found that Bam32 was required for optimal TCR-induced Erk activation, cytokine production, proliferation and actin-mediated spreading of CD4(+) T cells. These results indicate a novel pathway to Erk activation in T cells involving the adapter protein Bam32. |
