| First Author | Tokue M | Year | 2017 |
| Journal | Stem Cell Reports | Volume | 8 |
| Issue | 3 | Pages | 561-575 |
| PubMed ID | 28196692 | Mgi Jnum | J:257319 |
| Mgi Id | MGI:6119909 | Doi | 10.1016/j.stemcr.2017.01.006 |
| Citation | Tokue M, et al. (2017) SHISA6 Confers Resistance to Differentiation-Promoting Wnt/beta-Catenin Signaling in Mouse Spermatogenic Stem Cells. Stem Cell Reports 8(3):561-575 |
| abstractText | In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRalpha1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent of asymmetric division or definitive niche control. Here, we show that activation of Wnt/beta-catenin signaling promotes spermatogonial differentiation and reduces the GFRalpha1(+) cell pool. We further discovered that SHISA6 is a cell-autonomous Wnt inhibitor that is expressed in a restricted subset of GFRalpha1(+) cells and confers resistance to the Wnt/beta-catenin signaling. Shisa6(+) cells appear to show stem cell-related characteristics, conjectured from the morphology and long-term fates of T (Brachyury)(+) cells that are found largely overlapped with Shisa6(+) cells. This study proposes a generic mechanism of stem cell regulation in a facultative (or open) niche environment, with which different levels of a cell-autonomous inhibitor (SHISA6, in this case) generates heterogeneous resistance to widely distributed differentiation-promoting extracellular signaling, such as WNTs. |
