| First Author | Kobayashi M | Year | 1994 |
| Journal | Immunol Lett | Volume | 40 |
| Issue | 1 | Pages | 13-20 |
| PubMed ID | 7927508 | Mgi Jnum | J:18461 |
| Mgi Id | MGI:66743 | Doi | 10.1016/0165-2478(94)90199-6 |
| Citation | Kobayashi M, et al. (1994) Effect of a traditional Chinese herbal medicine, kanzo-bushi-to, on the production of interleukin-4 from a clone of burn-associated CD8+ suppressor T cells. Immunol Lett 40(1):13-20 |
| abstractText | Effect of Kanzo-bushi-to (TJS-038), one of the Japanese Kampo medicines originating from traditional Chinese herbal medicine, on the activity of a clone of burn-associated CD8+ suppressor T cells (T6S cells) was investigated. The suppressor cell activity of T6S cells in the mixed lymphocyte-tumor cell reaction (MLTR) was not changed when various concentrations of TJS-038 were added to the MLTR. The suppressor cell activity of T6S cells was greatly inhibited by CD3+ CD4+ CD28+ TCR alpha/beta+ Vicia villosa lectin-adherent cells (TJS cells) purified from spleen cells of mice treated with TJS-038 at an oral dose of 50 mg/kg. The suppressor cell activity of T6S cells was not demonstrated in the MLTR assay when anti-IL-4 monoclonal antibody was added. Also the production of IL-4 from T6S cells was not detected, when they were co-cultured with TJS cells. These results suggest that TJS-038 stimulates the generation of contrasuppressor T cells (TJS cells) that inhibit the suppressor cell activity of T6S cells and the production of IL-4 from T6S cells. |
