| First Author | Ogura Y | Year | 1998 |
| Journal | Biol Reprod | Volume | 58 |
| Issue | 1 | Pages | 65-72 |
| PubMed ID | 9472924 | Mgi Jnum | J:44830 |
| Mgi Id | MGI:1101376 | Doi | 10.1095/biolreprod58.1.65 |
| Citation | Ogura Y, et al. (1998) Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta. Biol Reprod 58(1):65-72 |
| abstractText | Platelet-derived growth factor receptor alpha (PDCFR alpha) is expressed in multiple tissues and exerts its function throughout mouse embryogenesis. Upon screening the PDCFR alpha-expressing tissues in mouse embryos by immunohistochemistry using our established monoclonal antibody against murine PDGFRa, we found its expression in an epithelium lining a sinusoidal structure in placenta. This structure was proven to be the sinus of Duval, and the PDGFR alpha-positive epithelium to be the intraplacental yolk sac (IPY). The IPY has been postulated to be a derivative of primitive endoderm because of its morphology and its expression of vitamin D-dependent 9-kDa calcium-binding protein, and to play some roles in materno- fetal transport. In this study, we demonstrated that the IPY develops from primitive endoderm by its invagination into chorioallantoic placenta and continues to strongly express PDCFR alpha until the prenatal stage. Moreover, we found that the IPY is completely absent in Pdgfra(Ph)/Pdgfra(Ph) mutant embryos, which lack the Pdgfra gene, suggesting that the function of PDGFR alpha is essential to its formation. Hence, PDGFR alpha expressed in the IPY should be listed as a component of the cytokine network of murine placental development. |
