| Primary Identifier | MGI:1289225 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 233724 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable phospholipid scramblase activity. Predicted to be involved in autophagosome assembly; intracellular lipid transport; and modulation by host of viral RNA genome replication. Predicted to act upstream of or within autophagy; lipid transport; and nervous system development. Located in mitochondria-associated endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human TMEM41B (transmembrane protein 41B). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit embryonic growth arrest and complete embryonic lethality between implantation and placentation. Mice heterozygous for a null allele display reduced serum lipid levels, impaired autophagic flux, and resistance to coronavirus infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
