| First Author | Lyddane C | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 6 | Pages | 3306-10 |
| PubMed ID | 16517696 | Mgi Jnum | J:129367 |
| Mgi Id | MGI:3769172 | Doi | 10.4049/jimmunol.176.6.3306 |
| Citation | Lyddane C, et al. (2006) Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization. J Immunol 176(6):3306-10 |
| abstractText | Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28(-/-) CD4(+)CD25(-) T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation. |
