| First Author | Van Nguyen T | Year | 2012 |
| Journal | Mol Cell | Volume | 45 |
| Issue | 2 | Pages | 210-21 |
| PubMed ID | 22284677 | Mgi Jnum | J:232386 |
| Mgi Id | MGI:5776682 | Doi | 10.1016/j.molcel.2011.12.026 |
| Citation | Van Nguyen T, et al. (2012) SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell 45(2):210-21 |
| abstractText | Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development. |
