Primary Identifier | MGI:5439016 | Allele Type | Targeted |
Gene | Il17a | Transmission | Germline |
Strain of Origin | 129S4/SvJae-Tg(Prm-cre)70Og | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The 3' untranslated region (UTR) was modified to include a floxed neo cassette, an internal ribosomal entry site (IRES) and a non-signaling form of the human nerve growth factor (NGFR) gene. This results in IRES mediated translation of NGFR when the endogenous locus is activated. Cre-mediated recombination removed the neo cassette. |