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Protein Coding Gene : Ptk2b PTK2 protein tyrosine kinase 2 beta

Primary Identifier  MGI:104908 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  19229
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of organelle organization. Acts upstream of with a positive effect on positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within cellular response to fluid shear stress. Located in nucleus and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and liver. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta).
PHENOTYPE: Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function. Homozygous KO also results in increased female fecundity. [provided by MGI curators]
  • synonyms:
  • Ptk2b,
  • RIKEN cDNA E430023O05 gene,
  • Raftk,
  • MGD-MRK-29062,
  • PYK2,
  • E430023O05Rik,
  • calcium-dependent tyrosine kinase,
  • PTK2 protein tyrosine kinase 2 beta,
  • MGI:2444305,
  • related adhesion focal tyrosine kinase,
  • proline-rich tyrosine kinase 2,
  • CAKbeta,
  • cellular adhesion kinase beta

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

15 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For